Lector Dr. Alina SESĂRMAN

PERSONAL

Discipline predate: Enzime si Biocataliza, Biochimia proteinelor cu elemente de proteomica, Biochimia glucidelor si lipidelor, Biochimie clinica

Tematici de cercetare:

(specifice grupului de cercetare din care fac parte)

identificarea mecanismelor care guvernează patogeneza bolilor autoimune și a cancerului
evaluarea eficacității antitumorale a diferiților agenți chimioterapeutici, utilizând modele in vitro 2D / 3D și modele animale

Publicatii relevante

Sesarman A, Sitaru AG, Olaru F, Zillikens D and Sitaru C. Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita. J Mol Med, 86:951-9, 2008.
Sesarman A, Vidarsson G and Sitaru C. The neonatal Fc receptor (FcRn) as therapeutic target in IgG-mediated autoimmune diseases. Cell Mol Life Sci, 67(15) 2533-2550, 2010.
Licarete E, Sesarman A and Banciu M. Exploitation of pleiotropic actions of statins by using tumor-targeted delivery systems. Journal of Microencapsulation, 32(7):619-31, 2015.
Sesarman, A., Tefas, L., Sylvester, B., Licarete, E., Rauca, V., Luput, L., Patras, L., Banciu, M., Porfire, A. Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells. Pharmacol Rep 70(2):331-339,
Sesarman A, Tefas L, Sylvester B, Licarete E, Rauca V, Luput L, et al. Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment. Drug Deliv Transl Res, 9(1):260–72, 2019.
Licarete E, Rauca VF, Luput L, Drotar D, Stejerean I, Patras L, Dume B, Toma VA, Porfire A, Gherman C, Sesarman A, Banciu M. Overcoming Intrinsic Doxorubicin. Resistance in Melanoma by Anti-Angiogenic and Anti-Metastatic Effects of Liposomal Prednisolone Phosphate on Tumor Microenvironment. Int J Mol Sci. 2020, Apr 23;21(8):2968

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Grupuri de cercetare

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