Lector Dr. Alina SESĂRMAN
Undergraduate/ postgraduate courses:
- Enzymes and biocatalyses
- Biochemistry of proteins and Introduction to Proteomics
- Biochemistry of Carbohydrates and Lipids
- Clinical biochemistry
Research interests:
- identifying the mechanisms governing the pathogenesis of diseases arising from aberrant function of the immune system: autoimmune diseases and cancer,
- evaluation of antitumor efficacy of various chemotherapeutic agents, using in vitro 2D/3D and in vivo models
Selected publications
- Sesarman A, Sitaru AG, Olaru F, Zillikens D and Sitaru C. Neonatal Fc receptor deficiency protects from tissue injury in experimental epidermolysis bullosa acquisita. J Mol Med, 86:951-9, 2008.
- Sesarman A, Vidarsson G and Sitaru C. The neonatal Fc receptor (FcRn) as therapeutic target in IgG-mediated autoimmune diseases. Cell Mol Life Sci, 67(15) 2533-2550, 2010.
- Licarete E, Sesarman A and Banciu M. Exploitation of pleiotropic actions of statins by using tumor-targeted delivery systems. Journal of Microencapsulation, 32(7):619-31, 2015.
- Sesarman, A., Tefas, L., Sylvester, B., Licarete, E., Rauca, V., Luput, L., Patras, L., Banciu, M., Porfire, A. Anti-angiogenic and anti-inflammatory effects of long-circulating liposomes co-encapsulating curcumin and doxorubicin on C26 murine colon cancer cells. Pharmacol Rep 70(2):331-339,
- Sesarman A, Tefas L, Sylvester B, Licarete E, Rauca V, Luput L, et al. Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment. Drug Deliv Transl Res, 9(1):260–72, 2019.
- Licarete E, Rauca VF, Luput L, Drotar D, Stejerean I, Patras L, Dume B, Toma VA, Porfire A, Gherman C, Sesarman A, Banciu M. Overcoming Intrinsic Doxorubicin. Resistance in Melanoma by Anti-Angiogenic and Anti-Metastatic Effects of Liposomal Prednisolone Phosphate on Tumor Microenvironment. Int J Mol Sci. 2020, Apr 23;21(8):2968
Weblinks of interest:
Pubmed
https://www.ncbi.nlm.nih.gov/pubmed/?term=sesarman+a
Research group:
http://centru3b.centre.ubbcluj.ro/en/nanomedicine-group/
Other weblinks of interest for students and collaborators: